She was caught shoplifting at the age of 12 and later shaved her head.
At the age of 14, she moved in with her sister Rosanna.
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She also earned critical acclaim for her work as an actress after co-starring with Reese Witherspoon and Beau Bridges in the 1991 Lifetime made-for-TV movie (1991), about two brothers on opposite sides of the law.
In the film, she played the girlfriend of Frank Roberts (Viggo Mortensen), a wayward criminal who tells his lawman brother Joe (David Morse) that he wants to reform himself.
Rosanna was an up-and-coming actress at the time who soon made it big with the 1985 hit (1987).
The following year, Arquette had her first child, a son named Enzo, with musician Paul Rossi.
After several rounds of separations and reconciliations, her marriage to Nicolas Cage also ended around this time. In this role, she plays the wife and mother of three who tries to balance her family life, her law school studies, and work with the police to solve cases.